SPA17 (sperm autoantigenic protein 17)

The antibody against a nuclear autoantigenic sperm protein can result in reproductive failure.

To study whether the antibody against the testis form of the nuclear autoantigenic sperm protein (tNASP) could result in reproductive failure, we successfully cloned and expressed a 339-bp cDNA fragment of mouse tNASP (mtNASP). Using mouse as a model, recombinant mtNASP (rmtNASP) and a synthetic peptide, human tNASP(393-408) (htNASP(393-408)), were investigated for their antifertility effect. A...

Sperm protein 17 is not expressed on normal leukocytes.

corticosteroids and/or chemotherapy, has so far shown efficacy in only a few cases of cold agglutinin disease.6-11 Asingle course of rituximab also has been used in combination with corticosteroids for the treatment of one case of idiopathic warm hemolytic anemia, leading only to a partial improvement of the hemoglobin level and hemolytic signs.12 Although further studies are warranted on large...

Characterization of Sperm Protein 17: A Primate Model

Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella

BACKGROUND Sperm protein 17 (Sp17) is a three-domain protein that contains: 1) a highly conserved N-terminal domain that is 45% identical to the human type II alpha regulatory subunit (RII alpha) of protein kinase A (PKA); 2) a central sulphated carbohydrate-binding domain; and 3) a C-terminal Ca++/calmodulin (CaM) binding domain. Although Sp17 was originally discovered and characterized in spe...

O-17: Study of Sperm Protein Profile in Oigo- and Normozoospermic Patients with Varicocele Using Two Dimensional Eectrophoresis

Background: The aim of this study was to compare the sperm protein profile between oligo- and normozoospermic patients with varicocele. Materials and Methods: Sperm samples of 20 normozoospermic and 20 oligozoospermic patients with varicocele were characterized using two dimensional electrophoresis (group 1 and group 2, respectively). Differences in protein expression were established using gel...